Relationship of blood glucose to changes in insulin sensitivity during insulin shock therapy.

  title={Relationship of blood glucose to changes in insulin sensitivity during insulin shock therapy.},
  author={I. F. Bennett and T. V. Letonoff and W. Winick and F. Dohan},
  journal={A.M.A. archives of neurology and psychiatry},
  volume={78 3},
The amount of insulin required to produce coma during the course of insulin shock therapy (IST) by the rapid induction method (Bond and Shurley1) is not constant but is considerably reduced after the first coma. We have previously observed (Dohan and associates2) that the mean lowest coma dose usually occurs in the fourth or fifth week of therapy and is approximately one-fourth or less of that required to produce the initial coma. Hypothetically, the most probable factors responsible for this… Expand


Insulin therapy and its future.
The discussion naturally begins with a description of the technique and the results, and it is admitted, however, that the authors are perhaps yet a long way from understanding the tnodus operandi of the response and often recovery of schizophrenic patients undergoing insulin therapy. Expand
A note on the level of glucose and of nonfermentable reducing substances in therapeutic insulin shock
Abstract The figures in Table I confirm other workers 2, 4, 9 in showing that the glucose may be determined with a probable error of ±2 mg. by subtracting 4 mg. from the blood sugar, as determinedExpand
Cerebral blood flow and metabolism in schizophrenia; the effects of barbiturate semi-narcosis, insulin coma and electroshock.
Although there were no demonstrable deviations from the normal in this group of schizophrenic patients, the experience with this technique leads us to believe that it is worthy of extensive application in the study of the metabolic derangements in the brain. Expand
The paradoxical effect of giant intravenous insulin doses on rabbits.
  • E. Naatanen
  • Medicine
  • Annales medicinae experimentalis et biologiae Fenniae
  • 1954