Relationship of aging and tobacco use with the development of aberrant crypt foci in a predominantly African-American population.

@article{Moxon2005RelationshipOA,
  title={Relationship of aging and tobacco use with the development of aberrant crypt foci in a predominantly African-American population.},
  author={Darran R Moxon and Mamoon Raza and Richard Kenney and Ronald Ewing and Ahsan M. Arozullah and Joel B. Mason and Robert E. Carroll},
  journal={Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association},
  year={2005},
  volume={3 3},
  pages={
          271-8
        }
}
BACKGROUND AND AIMS In clinical studies, diminished folate availability appears to increase the risk for colorectal neoplasms. Additionally, alcohol and tobacco use are associated with an increased risk for colon cancer, but the early pathologic events by which these agents promote neoplastic transformation are not well understood. Aberrant crypt foci (ACF) are potential precursors of adenoma and cancer, and can be visualized by magnification endoscopy. We hypothesized that folate depletion is… CONTINUE READING

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