Relationship of aberrant DNA hypermethylation of CHFR with sensitivity to taxanes in endometrial cancer.

@article{Yanokura2007RelationshipOA,
  title={Relationship of aberrant DNA hypermethylation of CHFR with sensitivity to taxanes in endometrial cancer.},
  author={Megumi Yanokura and Kouji Banno and Makiko Kawaguchi and Nobumaru Hirao and Akira Hirasawa and Nobuyuki Susumu and Katsumi Tsukazaki and Daisuke Aoki},
  journal={Oncology reports},
  year={2007},
  volume={17 1},
  pages={41-8}
}
The relationship of aberrant DNA hypermethylation of cell cycle checkpoint genes with the sensitivity of cancer cells to anticancer drugs is a question of current interest. In this study, we investigated the relationship between aberrant hypermethylation of the CHFR (checkpoint with forkhead-associated and ring finger) mitotic checkpoint gene and sensitivity to taxanes in endometrial cancer. Methylation-specific PCR (MSP) indicated aberrant hypermethylation of CHFR in 12.0% (6/50) of… CONTINUE READING
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