Relationship of aardvark to elephants, hyraxes and sea cows from α-crystallin sequences

  title={Relationship of aardvark to elephants, hyraxes and sea cows from $\alpha$-crystallin sequences},
  author={Wilfried W. de Jong and Anneke Zweers and Morris Goodman},
One of the great enigmas of mammalian phylogeny is the genealogical relationship of the aardvark (Orycteropus afer), the only living representative of the order Tubulidentata. Although now generally grouped close to the ungulates and paenungulates1–4, and thought to be derived from a common condylarthran stock5–7, it still holds an isolated position among eutherian mammals. The evidence of the evolutionary relationships of the aardvark may be obscured at the morphological and anatomical level… 

The mitochondrial DNA molecule of the aardvark, Orycteropus afer, and the position of the Tubulidentata in the eutherian tree

The aardvark tRNA–Ser(UCN) differs from that of other mammalian mtDNAs reported and appears to have reversed to the ancestral secondary structure of non–mammalian vertebrates and mitochondrial tRNAs in general.

Paenungulata: a comparison of the hemoglobin sequences from elephant, hyrax, and manatee.

Results obtained by parsimony analysis provide evidence for this grouping--and thus support for the genealogical validity of Simpson's superorder Paenungulata, which contains as the extant orders Proboscidea, Sirenia, and Hyracoidea.

Molecular Evolution of Mammalian Elephant Shrew and Aardvark Join the Paenungulate Clade

The AQP2 data set strongly supports a clade consisting of elephant, hyrax, aardvark, and elephant shrew, reaching bootstrap values of 99%.

Ancient SINEs from African endemic mammals.

A novel family of SINEs, designated AfroSines, was isolated and characterized from the genomes of afrotherians, suggesting monophyly of these three groups, which was previously proposed as Paenungulata.

Endemic African mammals shake the phylogenetic tree

DNA sequences from three mitochondrial genes and two nuclear genes are analysed to examine relationships of insectivores to other mammals and suggest that there was an extensive African radiation from a single common ancestor that gave rise to ecologically divergent adaptive types.

Molecular evolution of mammalian aquaporin-2: further evidence that elephant shrew and aardvark join the paenungulate clade.

The AQP2 data set, alone as well as in combination with previously published alpha A-crystallin protein sequences, strongly supports a clade consisting of elephant, hyrax, aardvark, and elephant shrew, reaching bootstrap values of 99%.

Afrotherian mammals: a review of current data

Molecular data suggest an African origin for Afrotheria and a long period of endemism on that continent, and paleontological data argue for the broad distribution of afrotherians during the Tertiary and do not exclude their Laurasian origin.

Eutherian phylogeny from a primate perspective

It is concluded that the substitution rate of antigenic determinants of serum proteins correlates positively with speciation frequency in a phyletic lineage and genetic drift influenced the rate of molecular evolution of mammalian orders to a different extent.

Phylogenetic Position of Mammoth and Steller's Sea Cow Within Tethytheria Demonstrated by Mitochondrial DNA Sequences

DNA sequences from mitochondrial cytochrome b gene segments for the extinct woolly mammoth and Steller's sea cow and the extant Asian elephant and the Western Indian manatee allow us to construct the phylogeny for the Tethytheria.

Cytochromeb gene of marine mammals: Phylogeny and evolution

Human and elephant cytochromeb amino acid sequences were found to evolve the most rapidly, while those of myomorph rodents evolved slowest, suggesting that the hippopotamus may be the extant artiodactyl species that is most closely related to the cetaceans.



The amino acid sequence of elephant (Elephas maximus) myoglobin and the phylogeny of Proboscidea

The complete amino acid sequence of skeletal myoglobin from the Asian elephant (Elephas maximus) is reported. The functional significance of variations seen when this sequence is compared with that

Phylogenetic Relationships and a Classification of the Eutherian Mammalia

It is remarkable that the enormous increase in the fossil evidence, new facts from the study of living mammals, and the promising rise of molecular studies have in fact had less than the usually


The therian mammals, marsupials and placentals with their ancestors, are an adaptively diverse group as well as a familiar one, so knowledge is less incomplete for therians than for other groups.

Toward a Phylogenetic Classification of the Mammalia

This short paper attempts to update certain aspects of my previous review by taking into account research published since 1969, as well as work being incorporated into a new classification of the Mammalia now being prepared which wall deal with all taxonomic levels down to the subgeneric level in essentially the same style as Simpson’s (1945) classification.

The Amino-Acid Sequence of the αA2 Chain of Bovine α-Crystallin

A high degree of homology between the αB2, and the αA2 chain, the major polypeptides, of bovine α-crystallin was observed.

Proof for the Maximum Parsimony (“Red King”) Algorithm

In this chapter, the highlights of the proof for the current computer algorithm for reconstructing hypothetical mRNA sequence ancestors consistent with contemporary amino acid sequences and the Red King hypothesis are reviewed.

The Amino‐Acid Sequences of the α‐Crystallin A Chains of Red Kangaroo and Virginia Opossum

The amino acid sequence of the A chain of the eye lens protein α-srystallin from the red kangaroo (Macropus rufus) was completely determined by manual Edman degradation of tryptic, thermolytic and