Relationship of IgG and IgM autoantibodies and immune complexes to oxidized LDL with markers of oxidation and inflammation and cardiovascular events: results from the EPIC-Norfolk Study.

@article{Ravandi2011RelationshipOI,
  title={Relationship of IgG and IgM autoantibodies and immune complexes to oxidized LDL with markers of oxidation and inflammation and cardiovascular events: results from the EPIC-Norfolk Study.},
  author={Amir Ravandi and S. Matthijs Boekholdt and Ziad Mallat and Philippa J. Talmud and John J. P. Kastelein and Nicholas J Wareham and Elizabeth R. Miller and Jo{\"e}lle B{\'e}nessiano and Alain Tedgui and Joseph L. Witztum and Kay-tee Khaw and Sotirios Tsimikas},
  journal={Journal of lipid research},
  year={2011},
  volume={52 10},
  pages={1829-36}
}
Levels of IgG and IgM autoantibodies (AA) to malondialdehyde (MDA)-LDL and apoB-immune complexes (ICs) were measured in 748 cases and 1,723 controls in the EPIC-Norfolk cohort and their association to coronary artery disease (CAD) events determined. We evaluated whether AA and IC modify CAD risk associated with secretory phospholipase A(2) (sPLA(2)) type IIA mass and activity, lipoprotein-associated PLA(2) activity, lipoprotein (a) [Lp(a)], oxidized phospholipids on apoB-100 (OxPL/apoB… CONTINUE READING