Relationship of HLA-A,-Cw polymorphisms with HIV/AIDS in Chinese Yi ethnic group of Sichuan province

  title={Relationship of HLA-A,-Cw polymorphisms with HIV/AIDS in Chinese Yi ethnic group of Sichuan province},
  author={Hong Kun-xue and Lu Xiao-zhi and Qin Guang-ming and Cheng Jian-ping and Ruan Yu-hua and Xing Hui and Zhu Jia-hong and Shao Yi-ming},
  journal={Virologica Sinica},
The relationship of HLA-A,-Cw alleles on HIV infection and AIDS disease progression in the Chinese Yi ethnic group of Sichuan province were investigated. The genetic polymorphisms of HLA-A,-Cw alleles of 102 unrelated healthy Chinese Yi ethnic individuals, 68 HIV-1 infected and 21 HIV positive long-time survivors were typed by PCR-SSP assay. Statistic significance was determined by the x2 test with the SPSS software. No significant differences were observed between the HLA-A,-Cw alleles of the… 
Association of HLA-A, B, DRB1 alleles and haplotypes with HIV-1 infection in Chongqing, China
These results may contribute to the database of HLA profiles in HIV-1 infected Chinese population, consequently, the association of certain HLA alleles with susceptibility or resistance to HIV-3 infection would provide with clues in choosing proper preventive strategies against HIV-2 infection and developing effective HIV- 1 vaccines in Chinese population.
High Resolution Human Leukocyte Antigen Class I Allele Frequencies and HIV-1 Infection Associations in Chinese Han and Uyghur Cohorts
Several HLA class I alleles and haplotypes were associated with lower HIV-1 susceptibility in a Chinese Han and a Chinese Uyghur cohort and could prove useful in the development of HIV- 1 vaccine candidates.


Accelerating Effect of Human Leukocyte Antigen-Bw6 Homozygosity on Disease Progression in Chinese HIV-1-Infected Patients
Genotyping of typical progressors and long-term nonprogressors in Chinese patients revealed some evidence that an HLA-B locus polymorphism can influence the rate of disease progression in Chinese HIV-1-infected individuals, and it was concluded that Hla-Bw4 homozygosity may have a protective role.
Studies of potential linkage between HLA class I alleles and HIV infection
Analysis of the frequencies of specific at the A, B, and C loci revealed a significantly higher frequency of B35 alleles among HIV infectious patients comparing with controls, and HLA-B35 allele are potentially associated with susceptible HIV infection.
Influence of HLA supertypes on susceptibility and resistance to human immunodeficiency virus type 1 infection.
Data provide further evidence that resistance to HIV-1 infection in this cohort of sex workers is immunologically mediated, and suggest that anti-HIV-1 class II restricted CD4 effector mechanisms may play an important role in protecting against viral challenge.
Influence of human leukocyte antigen-B22 alleles on the course of human immunodeficiency virus type 1 infection in 3 cohorts of white men.
White B22 serogroup alleles appear to predispose to unfavorable outcome of HIV infection as strongly as some or all B*35 and B*53 alleles, which may have greater implications for Asians, because the marker frequency for B22 is higher among Asians than among whites.
Study requirements for investigating HLA-associated progression of HIV disease, and review.
It is suggested that more rigorous analysis still requires an international multi-cohort analysis workshop to be convened to map HLA effects on HIV disease progression, and a partial validation of Kaslow's HLA profile score is presented, which models intermediate effects.
Evidence of HIV-1 Adaptation to HLA-Restricted Immune Responses at a Population Level
A fundamental role is supported for HLA-restricted immune responses in driving and shaping HIV-1 evolution in vivo and at a population level the degree of HLA–associated selection in viral sequence was predictive of viral load.
The influence of HLA genotype on AIDS.
The HLA associations with progression to AIDS that have been consistently affirmed are reviewed and the underlying mechanisms behind some of these associations are discussed based on functional studies of immune cell recognition.
Molecular typing for the MHC with PCR-SSP.
It was 5 years before its popularity erupted, mainly due to the work of Olerup & Zetterquist, who defined its potential for solid organ transplantation and it is now the method of choice for high resolution HLA typing in many laboratories.
Phototyping: comprehensive DNA typing for HLA-A, B, C, DRB1, DRB3, DRB4, DRB5 & DQB1 by PCR with 144 primer mixes utilizing sequence-specific primers (PCR-SSP).
The Phototyping set has been used as the sole method of HLA typing for over 1010 individuals and has capacity to detect new alleles, for example, novel amplification patterns suggestive of 4 new HLA-B alleles have been detected.
Data Analysis of Medical Genetics and Genetic Epidemiology
  • Haerbing: Helongjiang Science and Technology Press,
  • 1996