Relationship of DNA damage signaling to DNA replication following treatment with DNA topoisomerase inhibitors camptothecin/topotecan, mitoxantrone, or etoposide.

@article{Zhao2012RelationshipOD,
  title={Relationship of DNA damage signaling to DNA replication following treatment with DNA topoisomerase inhibitors camptothecin/topotecan, mitoxantrone, or etoposide.},
  author={Hong Zhao and Paulina Rybak and Jurek W. Dobrucki and Frank Traganos and Zbigniew Darzynkiewicz},
  journal={Cytometry. Part A : the journal of the International Society for Analytical Cytology},
  year={2012},
  volume={81 1},
  pages={
          45-51
        }
}
DNA topoisomerase I (Top1) and topoisomerase II (Top2) inhibitors are widely used to treat a variety of cancers. Their mechanism of action involves stabilization of otherwise transient ("cleavable") complexes between Top1 or Top2 and DNA; collisions of DNA replication forks with such stabilized complexes lead to formation of DNA double-strand breaks (DSBs). In this study, using 5-ethynyl-2'deoxyuridine (EdU) as a DNA precursor, we directly assessed the relationship between DNA replication and… CONTINUE READING
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