Relationship of Active Site Topology to Substrate Specificity for Cytochrome P 45 OteV ( CYP 108 )

  • Julia, Fruetel, +5 authors de Montellanos

Abstract

Earlier studies have shown that the reactions of cyto-chrome P450 with arylhydrazines yield aryl-iron complexes , and that oxidative migration of the aryl groups to the pyrrole nitrogens of the heme provides information on the active site topology. Comparison of cyto-chromes P450t,, (CyP108), P450,-(CYPlOl), and P450BM, (CyP102) by this method suggests that… (More)

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