Relationship between valproic acid dosage, plasma concentration and clearance in adult monotherapy patients with epilepsy.

@article{Gidal1995RelationshipBV,
  title={Relationship between valproic acid dosage, plasma concentration and clearance in adult monotherapy patients with epilepsy.},
  author={B E Gidal and Michael E. Pitterle and Nicholas Spencer and Marek Mal{\'y}},
  journal={Journal of clinical pharmacy and therapeutics},
  year={1995},
  volume={20 4},
  pages={215-9}
}
Significant variability has been reported in the plasma concentration-dose relationship for the anticonvulsant compound valproic acid (VPA). Several factors may contribute to this observed variability, including heterogeneous patient populations of children and adults, polytherapy, and timing of plasma concentration sampling. To optimally determine the relationship between trough VPA plasma concentration and dose, we evaluated a homogeneous group of adult ambulatory patients with epilepsy… CONTINUE READING

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