Relationship between tyramine potentiation and monoamine oxidase (MAO) inhibition: comparison between moclobemide and other MAO inhibitors

  title={Relationship between tyramine potentiation and monoamine oxidase (MAO) inhibition: comparison between moclobemide and other MAO inhibitors},
  author={Robert H. Zimmer},
  journal={Acta Psychiatrica Scandinavica},
  • R. Zimmer
  • Published 1990
  • Chemistry, Medicine
  • Acta Psychiatrica Scandinavica
The pharmacodynamic properties of moclobemide, a reversible inhibitor of MAO‐A (RIMA), were compared with the properties of other reversible as well as older irreversible MAO inhibitors in human subjects. All the substances supposed to have MAO‐A‐inhibitory activity, with the exception of toloxatone, were shown by the decrease in plasma DHPG or MHPG levels to cause inhibition ranging between 50% and 85%. Toloxatone and low doses of deprenyl (a MAO‐B inhibitor) caused 20% and 17% inhibition… Expand
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