Relationship between tumor necrosis factor-alpha and neutrophils in endotoxin-induced liver injury.

@article{Hewett1993RelationshipBT,
  title={Relationship between tumor necrosis factor-alpha and neutrophils in endotoxin-induced liver injury.},
  author={James A. Hewett and Paul A Jean and Steven L. Kunkel and Robert A. Roth},
  journal={The American journal of physiology},
  year={1993},
  volume={265 6 Pt 1},
  pages={G1011-5}
}
Tumor necrosis factor-alpha (TNF-alpha) and blood neutrophils (polymorphonuclear leukocytes; PMNs) have been implicated in the pathogenesis of endotoxin (lipopolysaccharide, LPS) hepatotoxicity. However, the mechanism by which these factors mediate liver injury during LPS exposure is uncertain. The objective of this study was to test the hypothesis that TNF-alpha contributes to LPS hepatotoxicity by an indirect, PMN-dependent mechanism. Pretreatment of rats with an antiserum to TNF-alpha… CONTINUE READING

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