Relationship between tumor enhancement, edema, IDH1 mutational status, MGMT promoter methylation, and survival in glioblastoma.

@article{Carrillo2012RelationshipBT,
  title={Relationship between tumor enhancement, edema, IDH1 mutational status, MGMT promoter methylation, and survival in glioblastoma.},
  author={J. A. Espich{\'a}n Carrillo and Albert Lai and Phioanh L. Nghiemphu and Hak Jin Kim and Heidi Phillips and Samir Kharbanda and Parham Moftakhar and S Lalaezari and W Yong and Benjamin M. Ellingson and Timothy F. Cloughesy and Whitney B. Pope},
  journal={AJNR. American journal of neuroradiology},
  year={2012},
  volume={33 7},
  pages={1349-55}
}
BACKGROUND AND PURPOSE Both IDH1 mutation and MGMT promoter methylation are associated with longer survival. We investigated the ability of imaging correlates to serve as noninvasive biomarkers for these molecularly defined GBM subtypes. MATERIALS AND METHODS MR imaging from 202 patients with GBM was retrospectively assessed for nonenhancing tumor and edema among other imaging features. IDH1 mutational and MGMT promoter methylation status were determined by DNA sequencing and methylation… CONTINUE READING

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