Relationship between toll-like receptor 2 Arg677Trp and Arg753Gln and toll-like receptor 4 Asp299Gly polymorphisms and cytomegalovirus infection.

@article{Jaboska2014RelationshipBT,
  title={Relationship between toll-like receptor 2 Arg677Trp and Arg753Gln and toll-like receptor 4 Asp299Gly polymorphisms and cytomegalovirus infection.},
  author={A Jabłońska and E Paradowska and Mirosława Studzińska and Patrycja Suski and Dorota Ewa Nowakowska and Małgorzata Wiśniewska-Ligier and Teresa Woźniakowska-Gęsicka and Jan Szczęsny Wilczyński and Zbigniew J Leśnikowski},
  journal={International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases},
  year={2014},
  volume={25},
  pages={11-5}
}
OBJECTIVES The association among specific single-nucleotide polymorphisms (SNPs) in TLR2 (Arg677Trp, Arg753Gln) and TLR4 (Asp299Gln) and human cytomegalovirus (CMV) infection was studied in infants and adults. METHODS The TLR2 and TLR4 polymorphisms were genotyped in 151 patients with CMV infections and in 78 unrelated healthy individuals. Genotyping was performed by restriction fragment length polymorphism (RFLP) analysis of PCR-amplified fragments. The viral load was measured by… CONTINUE READING