Relationship between timing of posterior neuropore closure and development of spinal neural tube defects in mutant (curly tail) and normal mouse embryos in culture.

@article{Copp1985RelationshipBT,
  title={Relationship between timing of posterior neuropore closure and development of spinal neural tube defects in mutant (curly tail) and normal mouse embryos in culture.},
  author={Andrew J Copp},
  journal={Journal of embryology and experimental morphology},
  year={1985},
  volume={88},
  pages={39-54}
}
  • Andrew J Copp
  • Published 1985 in Journal of embryology and experimental morphology
The relationship between timing of closure of the posterior neuropore (PNP) and development of spinal neural tube defects (NTD) has been studied in individual mutant curly tail mouse embryos maintained in culture. Moderate delay in PNP closure results in development of tail flexion defects whereas extreme delay of PNP closure is associated with development of open NTD. Experimental enlargement of the PNP at the stage of 25 to 29 somites leads to delayed PNP closure and development of tail… CONTINUE READING