Relationship between the tautomeric structures of curcumin derivatives and their Abeta-binding activities in the context of therapies for Alzheimer's disease.

Abstract

Curcumin, which can exist in an equilibrium between keto and enol tautomers, binds to beta-amyloid (Abeta) fibrils/aggregates. The aim of this study was to assess the relationship between the tautomeric structures of curcumin derivatives and their Abeta-binding activities. Curcumin derivatives with keto-enol tautomerism showed high levels of binding to… (More)
DOI: 10.1016/j.biomaterials.2010.01.142

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@article{Yanagisawa2010RelationshipBT, title={Relationship between the tautomeric structures of curcumin derivatives and their Abeta-binding activities in the context of therapies for Alzheimer's disease.}, author={Daijiro Yanagisawa and Nobuaki Shirai and Tomone Amatsubo and Hiroyasu Taguchi and Koichi Hirao and Makoto Urushitani and Shigehiro Morikawa and Toshiro Inubushi and Masanari G Kato and Fuminori Kato and Kyuya Morino and Hirohiko Kimura and Ichiro Nakano and Chikako Yoshida and Takashi Okada and Mitsuo Sano and Yoshiko Wada and Ken-nosuke Wada and Akitsugu Yamamoto and Ikuo Tooyama}, journal={Biomaterials}, year={2010}, volume={31 14}, pages={4179-85} }