Relationship between the plasma level of diphenylhydantoin sodium and its cardiac antiarrhythmic effects.

@article{Bigger1968RelationshipBT,
  title={Relationship between the plasma level of diphenylhydantoin sodium and its cardiac antiarrhythmic effects.},
  author={J. Thomas Bigger and Donald W. Schmidt and Henn Kutt},
  journal={Circulation},
  year={1968},
  volume={38 2},
  pages={363-74}
}
was studied in relation to its plasma levels. DPH was administered in one of three ways: (1) multiple intravenous doses, (2) single intravenous doses, and (3) oral doses. Ventricular arrhythmias occurring in many clinical conditions and atrial tachycardia, particularly if caused by digitalis excess, responded well to treatment with DPH. Three fourths of the responsive arrhythmias were abolished at plasma levels of DPH of 10 to 18 /tg/ml. In most cases a critical, effective plasma level could be… CONTINUE READING

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