Relationship between the native-state hydrogen exchange and the folding pathways of barnase.

@article{Chu1999RelationshipBT,
  title={Relationship between the native-state hydrogen exchange and the folding pathways of barnase.},
  author={Ruili Chu and Jiro Takei and Joseph J. Barchi and Yawen Bai},
  journal={Biochemistry},
  year={1999},
  volume={38 43},
  pages={
          14119-24
        }
}
The previous native-state hydrogen exchange experiment with barnase failed to detect any partially unfolded intermediate state which was contrary to the experimental results from kinetic deuterium hydrogen exchange pulse labeling and protein engineering studies. This has been taken to suggest that the native-state hydrogen exchange method cannot be used alone as an analytical tool to study the folding pathways of proteins. Here, we revisited the pulse labeling experiment with barnase and… CONTINUE READING
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