Relationship between the inhibition of receptor-induced increase in cytosolic free calcium concentration and the vasodilator effects of nitrates in patients with congestive heart failure.

@article{Negrescu1990RelationshipBT,
  title={Relationship between the inhibition of receptor-induced increase in cytosolic free calcium concentration and the vasodilator effects of nitrates in patients with congestive heart failure.},
  author={E. V. Negrescu and L. Sazonova and G. N. Baldenkov and N. M. Mukharliamov and A. Mazaev and V. Tkachuk},
  journal={International journal of cardiology},
  year={1990},
  volume={26 2},
  pages={
          175-84
        }
}
  • E. V. Negrescu, L. Sazonova, +3 authors V. Tkachuk
  • Published 1990
  • Medicine
  • International journal of cardiology
  • Nitroglycerin, isosorbide dinitrate and sodium nitroprusside, like nifedipine, were found to inhibit the receptor-provoked increase of cytosolic free calcium concentration in human platelets loaded with 2-[(2-amino-5-methylphenoxy)methyl]-6-methoxy-8-aminoquinoline-N,N,N',N' - tetraacetate. Sodium nitroprusside and nitroglycerin induced elevation of cyclic guanosine 3',5'-monophosphate content in platelets which correlated with their calcium-blocking activity. Methylene blue and epinephrine… CONTINUE READING
    23 Citations
    Direct inhibition of platelet function by organic nitrates via nitric oxide formation.
    • 55
    Mechanisms of action of nitrates
    • 81

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