Relationship between the infectivity of influenza virus and the ability of its fusion peptide to perturb bilayers.

The amino terminal segment of the HA2 protein of influenza virus has been identified as an important region for membrane fusion. We demonstrate that there is an association between the ability of model peptides corresponding to this region of the HA2 protein to promote the formation of inverted phases and the fusogenicity of the intact virus. The wild type… CONTINUE READING