Relationship between the genetically determined acetylator phenotype and DNA damage induced by hydralazine and 2-aminofluorene in cultured rabbit hepatocytes.

@article{Mcqueen1982RelationshipBT,
  title={Relationship between the genetically determined acetylator phenotype and DNA damage induced by hydralazine and 2-aminofluorene in cultured rabbit hepatocytes.},
  author={Charlene A. Mcqueen and Carol J. Maslansky and Irene B. Glowinski and S B Crescenzi and Wendell W. Weber and Gary M Williams},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1982},
  volume={79 4},
  pages={1269-72}
}
The relationship between acetylation rates of rabbit hepatocytes and their susceptibility to genotoxicity by DNA-damaging chemicals that undergo N-acetylation was studied in primary cultures of hepatocytes from New Zealand White rabbits that have a genetically determined difference in acetylation rates. Hepatocytes from rapid and slow acetylator rabbits maintained in culture the difference in acetylation rates that existed in vivo, DNA repair, an index of DNA damage, was produced by hydralazine… CONTINUE READING