• Corpus ID: 11059977

Relationship between the chemical structures and biological activities (toxicity, mutagenic and antitumor) in newly synthesized derivatives of pyrazolo pyrimidines.

@article{Nersesyan2006RelationshipBT,
  title={Relationship between the chemical structures and biological activities (toxicity, mutagenic and antitumor) in newly synthesized derivatives of pyrazolo pyrimidines.},
  author={Armen Nersesyan and Rafael Muradyan and Flora G. Arsenyan and Gevorg G. Danagulyan},
  journal={TSitologiia i genetika},
  year={2006},
  volume={40 6},
  pages={
          28-32
        }
}
The relationship between chemical structure, micronucleus-inducing and antitumor activities was studied in four newly synthesized pyrazolo pyrymidine compounds (DGB-216, DGB-227, DGB-228 and DGB-331). In bone marrow erythrocytes of mice no one of compounds was active. Only DGB-216 has slight antitumor activity and increases the mean life span of mice with Ehrlich ascite carcinoma by 11%, while others were practically non-active. Changes in the chemical structures of the compounds lead to… 
Ação antiinflamatória, imunomoduladora e citotóxica do composto RDV 8
TLDR
Results indicate a high immunomodulatory and antiinflammatory action of RDV 8 without any cytotoxic action on the concentrations used in these experiments.