Relationship between the Serotonergic Activity and Reinforcing Effects of a Series of Amphetamine Analogs

  title={Relationship between the Serotonergic Activity and Reinforcing Effects of a Series of Amphetamine Analogs},
  author={Sunmee Wee and Karen G. Anderson and Michael H Baumann and Richard B. Rothman and Bruce E. Blough and W. L. Woolverton},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  pages={848 - 854}
It has been reported that among drugs with mixed actions on central nervous system monoamine systems, increased serotonergic activity is associated with decreased potency as a reinforcer. The present experiment was designed to examine this relationship for amphetamine analogs that varied in serotonin releasing potency and to evaluate whether serotonergic actions can affect reinforcing efficacy. Compounds PAL 313 and 314 are para- and meta-methylamphetamine, respectively. PAL 303 and 353 are… 

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