Relationship between stress protein induction in rat kidney by mercuric chloride and nephrotoxicity.

@article{Goering1992RelationshipBS,
  title={Relationship between stress protein induction in rat kidney by mercuric chloride and nephrotoxicity.},
  author={Peter L. Goering and Benjamin R Fisher and Prem Prashant Chaudhary and Colin A J Dick},
  journal={Toxicology and applied pharmacology},
  year={1992},
  volume={113 2},
  pages={184-91}
}
Adverse environmental stimuli increase the synthesis of a class of proteins referred to as stress proteins. The effect of mercuric chloride, a model nephrotoxin, on protein synthesis in male rat kidney has been evaluated. Renal slices from exposed rats were incubated with [35S]methionine for 1 hr and subjected to SDS-PAGE, after which 35S-labeled proteins were detected by autoradiography. Enhanced de novo synthesis of 70- and 90-kDa relative molecular mass (M(r)) proteins were detected 2 hr… CONTINUE READING