Relationship between serum and free interstitial concentrations of cefodizime and cefpirome in muscle and subcutaneous adipose tissue of healthy volunteers measured by microdialysis.

@article{Mller1997RelationshipBS,
  title={Relationship between serum and free interstitial concentrations of cefodizime and cefpirome in muscle and subcutaneous adipose tissue of healthy volunteers measured by microdialysis.},
  author={Markus Michael M{\"u}ller and Beate Rohde and Andreas Kovar and Angeliki Georgopoulos and H. G. Eichler and Hartmut Derendorf},
  journal={Journal of clinical pharmacology},
  year={1997},
  volume={37 12},
  pages={1108-13}
}
Microdialysis is a suitable method to monitor unbound concentrations of antimicrobial drugs in the interstitial tissue space which is the site of many infections. The aim of this investigation was to examine whether free tissue levels of cefodizime (81% plasma protein binding) and cefpirome (10% plasma protein binding) in muscle and subcutaneous adipose tissue of healthy volunteers obtained by microdialysis are consistent with the extent of their respective plasma protein binding. Healthy… CONTINUE READING