Relationship between risperidone and 9-hydroxy-risperidone plasma concentrations and CYP2D6 enzyme activity in psychiatric patients.

@article{Berecz2002RelationshipBR,
  title={Relationship between risperidone and 9-hydroxy-risperidone plasma concentrations and CYP2D6 enzyme activity in psychiatric patients.},
  author={Roland Berecz and Adri{\'a}n Llerena and Alfredo de la Rubia and Juan-Carlos Gomez and Michael Kellermann and Pedro Dorado and Istv{\'a}n Degrell},
  journal={Pharmacopsychiatry},
  year={2002},
  volume={35 6},
  pages={231-4}
}
The implication of cytochrome P450 CYP2D6 enzyme activity in the metabolism of the antipsychotic drug risperidone has been reported in vitro and in studies of healthy volunteers. Around 7 % of Caucasians have inherited impaired capacity of this enzyme (poor metabolisers). These subjects might be prone to higher plasma concentrations of risperidone. The aim of the study was to determine the relationship between the debrisoquine metabolic ratio (MR), a marker of CYP2D6 enzyme activity, and… CONTINUE READING
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