Relationship between retinol and risk of diabetic retinopathy: a case-control study.

@article{Zhang2019RelationshipBR,
  title={Relationship between retinol and risk of diabetic retinopathy: a case-control study.},
  author={Chunmei Zhang and Kelei Li and Jiayu Zhang and Xiaotong Kuang and Chunxiao Liu and Qingxue Deng and Duo Li},
  journal={Asia Pacific journal of clinical nutrition},
  year={2019},
  volume={28 3},
  pages={
          607-613
        }
}
BACKGROUND AND OBJECTIVES The aim of the present study was to evaluate the relationship between retinol and risk of diabetic retinopathy in Chinese adults. METHODS AND STUDY DESIGN Eighty-six subjects with type 2 diabetes mellitus (T2DM) and 40 healthy subjects (healthy comparison group, HCG) were recruited in Beijing Luhe Hospital. Of the 86 T2DM subjects, 43 subjects were diagnosed with diabetic retinopathy (DRG), and 43 subjects had no retinopathy (DNRG). RESULTS Dietary intake of… Expand
3 Citations
Association between retinol binding protein 4 and diabetic retinopathy among type 2 diabetic patients: a meta-analysis
TLDR
Elevated RBP4 is strongly associated with DR and may play an essential role in its progression and additional large-scale controlled studies are needed to confirm these findings. Expand
Diagnostic circulating biomarkers to detect vision-threatening diabetic retinopathy: Potential screening tool of the future?
TLDR
Evaluating and reviewing data on circulating protein biomarkers, which have been verified in the context of diabetic retinopathy, and their potential integration into simple point-of-care testing devices are discussed. Expand
Antioxidants for the Treatment of Retinal Disease: Summary of Recent Evidence
TLDR
The mechanisms of retinal oxidative stress are described, the current available evidence for antioxidants as a treatment for vitreoretinal disorders is summarized and the role of antioxidants asA therapeutic treatment shows promise in slowing the progression of certain diseases. Expand

References

SHOWING 1-10 OF 20 REFERENCES
Serum Retinol-Binding Protein 4 Levels in Patients with Diabetic Retinopathy
Retinol-binding protein 4 (RBP4) has been reported to be involved in the development of insulin resistance and diabetes. This study was designed to investigate serum levels of RBP4 in patients withExpand
Elevated RBP4 plasma levels were associated with diabetic retinopathy in type 2 diabetes
TLDR
It is shown that elevated plasma levels of RBP4 were associated with DR and VDTR in Chinese patients with type 2 diabetes, suggesting a possible role ofRBP4 in the pathogenesis of DR complications. Expand
Vitamin A, retinol binding protein and lipids in type 1 diabetes mellitus
TLDR
The results suggest that vitamin A therapeutic supplements in IDDM children may reduce or prevent atherogenic risk and vitamin A ‘relative deficiency’ risk than those with good metabolic control of their illness. Expand
Low Serum Levels of Prealbumin, Retinol Binding Protein, and Retinol Are Frequent in Adult Type 1 Diabetic Patients
TLDR
Low serum levels of PA, RBP, and retinol are frequent in T1D adult patients and this alteration is influenced by female sex and serum creatinine and triglyceride levels. Expand
Effect of Metabolic Control on Serum Protein Concentrations in Diabetes
TLDR
Although reductions in glycated albumin and transferrin indicated improvement in blood glucose control, there was no correlation between changes in the glycated markers and the concentrations of serum transport proteins, and serum protein concentrations were influenced by the metabolic control of diabetes, but did not directly reflect blood glucose. Expand
Plasma Retinol-Binding Protein-4 Concentrations Are Elevated in Human Subjects With Impaired Glucose Tolerance and Type 2 Diabetes
TLDR
Plasma RBP4 concentrations were found to be elevated in subjects with IGT or type 2 diabetes and to be related to various clinical parameters known to be associated with insulin resistance. Expand
The Wisconsin epidemiologic study of diabetic retinopathy. II. Prevalence and risk of diabetic retinopathy when age at diagnosis is less than 30 years.
In a population-based study in southern Wisconsin, 996 insulin-taking, younger-onset diabetic persons were examined using standard protocols to determine the prevalence and severity of diabeticExpand
Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects.
TLDR
RBP4 is an adipocyte-secreted molecule that is elevated in the serum before the development of frank diabetes and appears to identify insulin resistance and associated cardiovascular risk factors in subjects with varied clinical presentations, providing a rationale for antidiabetic therapies aimed at lowering serum RBP4 levels. Expand
Biochemical indicators of vitamin A deficiency: serum retinol and serum retinol binding protein.
TLDR
More efforts to establish a reliable cut-off for RBP are warranted, because analysis, in particular radial immunodiffusion (RID), is relatively simple and inexpensive and methods are being developed for assessing serum retinol and RBP under more remote conditions. Expand
Comparison of nutrient intakes in South Asians with type 2 diabetes mellitus and controls living in the United States.
TLDR
SA with T2DM, compared to controls, consume less total energy and have lower consumption of many nutrients associated with reduced risk of T2 DM. Expand
...
1
2
...