Relationship between response and survival in more than 50,000 patients with advanced non-small cell lung cancer treated with systemic chemotherapy in 143 phase III trials.

@article{Hotta2007RelationshipBR,
  title={Relationship between response and survival in more than 50,000 patients with advanced non-small cell lung cancer treated with systemic chemotherapy in 143 phase III trials.},
  author={Katsuyuki Hotta and Yoshiro Fujiwara and Katsuyuki Kiura and Nagio Takigawa and Masahiro Tabata and Hiroshi Ueoka and Mitsune Tanimoto},
  journal={Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer},
  year={2007},
  volume={2 5},
  pages={402-7}
}
BACKGROUND The association between the objective response to chemotherapy and survival has not yet been fully evaluated using large cohorts in advanced non-small cell lung cancer. METHODS We searched for phase III trials conducted between 1991 and 2006 to investigate the role of systemic chemotherapy for advanced non-small cell lung cancer. Associations were tested by multiple regression analysis. RESULTS Of the 1255 trials screened, 143 met our criteria, involving 50,569 patients with 309… CONTINUE READING

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