Relationship between red meat allergy and sensitization to gelatin and galactose-α-1,3-galactose.

@article{Mullins2012RelationshipBR,
  title={Relationship between red meat allergy and sensitization to gelatin and galactose-$\alpha$-1,3-galactose.},
  author={R. Mullins and H. James and T. Platts-Mills and S. Commins},
  journal={The Journal of allergy and clinical immunology},
  year={2012},
  volume={129 5},
  pages={
          1334-1342.e1
        }
}
BACKGROUND We have observed patients clinically allergic to red meat and meat-derived gelatin. OBJECTIVE We describe a prospective evaluation of the clinical significance of gelatin sensitization, the predictive value of a positive test result, and an examination of the relationship between allergic reactions to red meat and sensitization to gelatin and galactose-α-1,3-galactose (α-Gal). METHODS Adult patients evaluated in the 1997-2011 period for suspected allergy/anaphylaxis to medication… Expand
Diagnosis of red meat allergy with antigen-specific IgE tests in serum.
TLDR
It is found that measurement of α-gal-specific IgE using the bovine thyroglobulin (bTG) ImmunoCAP method had the best overall sensitivity and specificity for diagnosis of red meat allergy and is the most useful for establishing a diagnosis. Expand
SENSITIZATION TO THE MAMMALIAN OLIGOSACCHARIDE GALACTOSE-ALPHA-1,3- GALACTOSE (ALPHA-GAL): EXPERIENCE IN A FLEMISH CASE SERIES
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This series confirms the importance of the α-gal carbohydrate moiety as a potential target for allergy to mammalian meat, dairy products and gelatin in a Flemish population of meat allergic adults and confirms in vitro tests to mammalianMeat generally to be more reliable than mammalian meat skin tests, but that diagnosis can benefit from skin testing with cetuximab. Expand
Galactose-Alpha-1,3-Galactose, Mammalian Meat and Anaphylaxis: A World-Wide Phenomenon?
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Mammalian meat allergies are characterised by delayed anaphylaxis, urticaria and angioedema, occurring 2–10 h after the ingestion of mammalian meat and are commonly preceded by a tick bite. Expand
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It is reported that in vivo basophil activation during a food challenge occurs in the same time frame as clinical symptoms and likely reflects the appearance of the antigen in the bloodstream. Expand
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The study concludes that a diagnosis of alpha-gal allergy should be considered in patients with urticaria-anaphylaxis of uncertain origin or manifesting after the administration of vaccines or products of bovine/porcine origin. Expand
Food allergy to the carbohydrate galactose-alpha-1,3-galactose (alpha-gal): four case reports and a review
TLDR
In four cases, one patient with a late onset of meat allergy had a history of a tick bite, indicating that in some patients, other ways of sensitisation may also take place, and in patients without atopy, tick bite-induced IgE to alpha-gal may be more relevant. Expand
The red meat allergy syndrome in Sweden
TLDR
The α-Gal carbohydrate has shown to be a potentially clinically relevant allergen that should be taken into account in the diagnosis of food allergy. Expand
The red meat allergy syndrome in Sweden
SummaryIn the last decade, a novel type of food allergy presenting with severe allergic reactions several hours after consumption of red meat has been recognized. The allergic responses are due toExpand
Red meat allergy in children and adults
TLDR
Red meat allergy is more common than previously appreciated and relates to at least three different forms that are distinguished by mechanisms of sensitization and have characteristic clinical and immunologic features. Expand
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