Relationship between rat renal accumulation of gentamicin, tobramycin, and netilmicin and their nephrotoxicities.

@article{Brier1985RelationshipBR,
  title={Relationship between rat renal accumulation of gentamicin, tobramycin, and netilmicin and their nephrotoxicities.},
  author={M. E. Brier and Philip R. Mayer and R A Brier and Daniel W. Visscher and Friedrich C. Luft and George R. Aronoff},
  journal={Antimicrobial agents and chemotherapy},
  year={1985},
  volume={27 5},
  pages={812-6}
}
Gentamicin, tobramycin, and netilmicin were given to rats in daily doses of either 5 or 20 mg/kg for 30 days to determine the renal accumulation kinetics of the compounds and to correlate steady-state renal parenchymal concentrations with nephrotoxicity. Four rats from each group were sacrificed daily and renal parenchymal tissue concentrations were determined microbiologically. Nephrotoxicity was assessed by changes in creatinine values in serum, renal creatinine clearances, and pathological… CONTINUE READING

References

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Pharmacokinetics, 2nd ed

  • M. Gibaldi, D. Perrier
  • 1982

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