Relationship between proliferation and susceptibility to CD95- and CD2-mediated apoptosis in stimulated primary T lymphocytes: T cells manifesting proliferative unresponsiveness are preferentially susceptible to CD95-mediated apoptosis.

Abstract

We examined the relationship between proliferation and susceptibility to Fas- and CD2-mediated apoptosis of human peripheral T lymphocytes that had been exposed in primary culture to CD3- or CD2-derived mitogenic stimuli in the presence of monocytes and exogenous IL-2. After 5 days, activated T cells were fractionated into large (F2) and small (F6) cells on… (More)

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@article{Mollereau1997RelationshipBP, title={Relationship between proliferation and susceptibility to CD95- and CD2-mediated apoptosis in stimulated primary T lymphocytes: T cells manifesting proliferative unresponsiveness are preferentially susceptible to CD95-mediated apoptosis.}, author={Bertrand Mollereau and D. Caroline Blanchard and Olivier D{\'e}as and C. Dumont and Didier M{\'e}tivier and A. Bernard and Jeffrey T McGrew and Beth Charpentier and A. V{\'a}zquez and Anna Senik}, journal={Journal of immunology}, year={1997}, volume={159 6}, pages={2668-77} }