Relationship between polymorphism in the manganese superoxide dismutase gene and breast cancer.

@article{ErasErdogan2009RelationshipBP,
  title={Relationship between polymorphism in the manganese superoxide dismutase gene and breast cancer.},
  author={N Eras-Erdogan and Etem Akbaş and H Senli and Seval Kul and Taner Çolak},
  journal={Mutation research},
  year={2009},
  volume={680 1-2},
  pages={7-11}
}
Manganese superoxide dismutase (MnSOD) acts as an antioxidant and protects cells from the harmful effects of reactive oxygen species. We investigated the relationship between the MnSOD Ala-9Val polymorphism and breast cancer. Genotypes of 250 cases and 330 controls were determined by use of PCR-RFLP. Compared with the MnSOD Val/Val genotype, the MnSOD Val/Ala or MnSOD Ala/Ala genotype was not significantly associated with the overall risk for breast cancer. The risk increased in women with… CONTINUE READING

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