Relationship between polymerase gamma (POLG) polymorphisms and antiretroviral therapy-induced lipodystrophy in HIV-1 infected patients: a case-control study.

@article{Chiappini2009RelationshipBP,
  title={Relationship between polymerase gamma (POLG) polymorphisms and antiretroviral therapy-induced lipodystrophy in HIV-1 infected patients: a case-control study.},
  author={Franck Chiappini and Elina Teicher and Rapha{\"e}l Saffroy and Brigitte Debuire and Daniel Vittecoq and Antoinette Lemoine},
  journal={Current HIV research},
  year={2009},
  volume={7 2},
  pages={244-53}
}
Nucleoside Reverse Transcriptase Inhibitors (NRTIs) used for the treatment of HIV-1 inhibit the replication of mitochondrial DNA (mtDNA), which may contribute to severe mitochondrial toxicity including lipodystrophy, through the inhibition of polymerase gamma (POLG). Polymorphisms of POLG could explain the variation in mitochondrial toxicity in HIV-1-infected patients. We explored the relationship between selected polymorphisms of POLG and lipodystrophy related to NRTIs. We studied single… CONTINUE READING
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