Relationship between plasma concentrations of clonidine and mean arterial pressure during an accidental clonidine overdose.

Abstract

The time course of toxicity in a 28 year old man following a 100 mg accidental overdose of clonidine hydrochloride is compared with the decline of plasma clonidine over 5 days. The concentration data were analyzed by nonlinear least squares regression, and fitted to a model which dissociated the blood pressure effects into pressor and depressor components… (More)

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@article{Domino1986RelationshipBP, title={Relationship between plasma concentrations of clonidine and mean arterial pressure during an accidental clonidine overdose.}, author={Laurel Domino and Stefan Domino and M S Stockstill}, journal={British journal of clinical pharmacology}, year={1986}, volume={21 1}, pages={71-4} }