Relationship between plasma concentrations of beta-carotene and alpha-tocopherol and life-style factors and levels of DNA adducts in lymphocytes.

@article{Wang1997RelationshipBP,
  title={Relationship between plasma concentrations of beta-carotene and alpha-tocopherol and life-style factors and levels of DNA adducts in lymphocytes.},
  author={Youdong Wang and Masayoshi Ichiba and Haruki Oishi and M Iyadomi and Naoko Shono and Katsumaro Tomokuni},
  journal={Nutrition and cancer},
  year={1997},
  volume={27 1},
  pages={69-73}
}
beta-Carotene and alpha-tocopherol have been thought to reduce risk of lung cancer. Whether beta-carotene and alpha-tocopherol influence human DNA adducts, indicators of biologically effective doses of carcinogens, has been seldom studied. In this cross-sectional study, we measured plasma beta-carotene and alpha-tocopherol in 192 healthy men and DNA adducts in lymphocytes in 104 of the subjects. Because genetic polymorphism of cytochrome P-4501A1 (CYP1A1) and glutathione S-transferase M1 (GSTM1… CONTINUE READING
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