Relationship between plasma concentrations and analgesia after intravenous fentanyl and disposition after other routes of administration in cats.

@article{Robertson2005RelationshipBP,
  title={Relationship between plasma concentrations and analgesia after intravenous fentanyl and disposition after other routes of administration in cats.},
  author={Sheilah Ann Robertson and Patricia M. Taylor and John William Sear and G Keuhnel},
  journal={Journal of veterinary pharmacology and therapeutics},
  year={2005},
  volume={28 1},
  pages={
          87-93
        }
}
Data allowing rational use of analgesics in cats are limited. Pharmacokinetics and pharmacodynamics of fentanyl were studied in cats. Plasma fentanyl concentrations were measured using radioimmunoassay in a crossover study in six cats after 10 microg/kg (i.v.) or by application of fentanyl in pluronic lecithin organogel (PLO) to the inner ear pinna. On a separate occasion thermal thresholds were measured after i.v. fentanyl (10 microg/kg) or saline. Plasma fentanyl concentrations reached 4.7-8… CONTINUE READING