• Corpus ID: 38238971

Relationship between plasma ACE activity and the prolif- erative healing process in coronary vessel injury after coronary stenting

@inproceedings{2000RelationshipBP,
  title={Relationship between plasma ACE activity and the prolif- erative healing process in coronary vessel injury after coronary stenting},
  author={},
  year={2000}
}
  • Published 2000
  • Biology, Medicine
The recent publication by Agerholm-Larsen B. et al. addressed the important issue of the degree of association between the insertion/deletion (I/D) polymorphism of the angiotensin converting enzyme (ACE) gene and its phenotypic expression in terms of basal plasma level of the enzyme in a large population of healthy Danes [1]. The I/D polymorphism explained up to 30–40% of the total phenotypic variance of plasma ACE level in women and men irrespective of age. This is in agreement with previous… 

Figures from this paper

References

SHOWING 1-10 OF 17 REFERENCES

D allele of the angiotensin I-converting enzyme is a major risk factor for restenosis after coronary stenting.

The results suggest that the renin-angiotensin system may be implicated in the pathogenesis of restenosis after coronary stenting.

Plasma activity and insertion/deletion polymorphism of angiotensin I-converting enzyme: a major risk factor and a marker of risk for coronary stent restenosis.

In a selected cohort of patients, both the D/D genotype of the ACE gene, and high plasma activity of the enzyme are significantly associated with in-stent restenosis.

Relation between the deletion polymorphism of the angiotensin-converting enzyme gene and late luminal narrowing after coronary angioplasty.

In this quantitative study, the I/D polymorphism of the ACE gene had no influence on the occurrence of restenosis after coronary angioplasty.

Plasma angiotensin-converting enzyme activity and left ventricular dilation after myocardial infarction.

Elevated plasma ACE activity determined soon after the onset of MI may be a significant predictor of the development of left ventricular dilation and may identify patients at risk.

Potential Importance of Tissue Angiotensin‐Converting Enzyme Inhibition in Preventing Neointima Formation

A dissociation of the ability of an ACE inhibitor to decrease blood pressure and inhibit circulating ACE activity from its ability to inhibit tissue ACE activity is demonstrated.

ACE gene polymorphism: ischemic heart disease and longevity in 10,150 individuals. A case-referent and retrospective cohort study based on the Copenhagen City Heart Study.

In two large studies, a case-referent study and a retrospective cohort study in an ethnically homogeneous white population, there was no evidence for a statistically significant difference in the development of myocardial infarction or any other manifestations of ischemic heart disease between genotype classes of the ACE gene polymorphism in either women or men.

Pathology of acute and chronic coronary stenting in humans.

Morphology after coronary stenting demonstrates early thrombus formation and acute inflammation followed by neointimal growth, and deployment strategies that reduce medial damage and avoid stent oversizing may lower the frequency of in-stent restenosis.

An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels.

The insertion/deletion polymorphism accounted for 47% of the total phenotypic variance of serum ACE, showing that the ACE gene locus is the major locus that determines serum ACE concentration.