Relationship between permeability status of the blood-brain barrier and in vitro permeability coefficient of a drug.

@article{Gaillard2000RelationshipBP,
  title={Relationship between permeability status of the blood-brain barrier and in vitro permeability coefficient of a drug.},
  author={Pieter Jaap Gaillard and Albertus G de Boer},
  journal={European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences},
  year={2000},
  volume={12 2},
  pages={95-102}
}
OBJECTIVE The aim was to test the hypothesis that the assessment of basal and drug-induced changes in permeability of the blood-brain barrier (BBB) during in vitro drug transport assays is essential for an accurate estimation of the permeability coefficient of a drug. METHODS An in vitro BBB model was used, comprising of brain capillary endothelial cells (BCEC) and astrocytes co-cultured on semi-permeable filter inserts. Experiments were performed under control and challenged experimental… CONTINUE READING

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