Relationship between peripheral airway dysfunction, airway obstruction, and neutrophilic inflammation in COPD.

@article{ODonnell2004RelationshipBP,
  title={Relationship between peripheral airway dysfunction, airway obstruction, and neutrophilic inflammation in COPD.},
  author={Rory A O'Donnell and Carol Peebles and Janet A Ward and A Daraker and Gilbert Angco and Pernilla Broberg and Stefan Pierrou and J Lund and Stephen T. Holgate and Donna E Davies and David Delany and Susan J. Wilson and Ratko Djukanovi{\'c}},
  journal={Thorax},
  year={2004},
  volume={59 10},
  pages={837-42}
}
BACKGROUND Considerable research has been conducted into the nature of airway inflammation in chronic obstructive pulmonary disease (COPD) but the relationship between proximal airways inflammation and both dynamic collapse of the peripheral airways and HRCT determined emphysema severity remains unknown. A number of research tools have been combined to study smokers with a range of COPD severities classified according to the GOLD criteria. METHODS Sixty five subjects (11 healthy smokers, 44… CONTINUE READING
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