Relationship between p53 gene mutations and multidrug resistance (mdr1) gene expression in myelodysplastic syndromes.

@article{Preudhomme1993RelationshipBP,
  title={Relationship between p53 gene mutations and multidrug resistance (mdr1) gene expression in myelodysplastic syndromes.},
  author={Claude Joseph Preudhomme and Pascale Lepelley and Anne Vach{\'e}e and Val{\'e}rie Soenen and Bruno Quesnel and Alain Cosson and Pierre Fenaux},
  journal={Leukemia},
  year={1993},
  volume={7 11},
  pages={1888-90}
}
P glycoprotein, the product of multidrug resistance (mdr1) gene, is frequently expressed in advanced myelodysplastic syndromes (MDS) with an excess of bone marrow blasts and could explain their frequent resistance to chemotherapy. P53 gene mutations are also found in 10 to 15% of advanced MDS. Because it has recently been suggested that normal p53… CONTINUE READING

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