Relationship between oestrogen receptor status and proliferation in predicting response and long-term outcome to neoadjuvant chemotherapy for breast cancer

@article{Jones2009RelationshipBO,
  title={Relationship between oestrogen receptor status and proliferation in predicting response and long-term outcome to neoadjuvant chemotherapy for breast cancer},
  author={Robin L Jones and Janine Salter and Roger P. A’Hern and Ash Nerurkar and Marina Parton and Jorge S Reis-Filho and Ian E. Smith and Mitchell Dowsett},
  journal={Breast Cancer Research and Treatment},
  year={2009},
  volume={119},
  pages={315-323}
}
Oestrogen receptor (ER) negative breast cancers are more likely to achieve a pathological complete response (pCR) to neoadjuvant chemotherapy compared to those with ER positive tumours. ER positive tumours exhibit low proliferation and ER negative cancers high proliferation. The aim of this study was to determine to what extent the better response of ER negative cancers correlates with proliferation rate. A retrospective analysis of a prospectively maintained database identified 175 neoadjuvant… CONTINUE READING
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