Relationship between nicotine dependence and the endophenotype-related trait of cognitive function but not acoustic startle reponses in Japanese patients with schizophrenia.

@article{Kishi2013RelationshipBN,
  title={Relationship between nicotine dependence and the endophenotype-related trait of cognitive function but not acoustic startle reponses in Japanese patients with schizophrenia.},
  author={Taro Kishi and Yasuhisa Fukuo and Tomo Okochi and Kunihiro Kawashima and Masatsugu Moriwaki and Osamu Furukawa and Giovanna M. Musso and Kiyoshi Fujita and Christoph U Correll and Nakao Iwata},
  journal={Human psychopharmacology},
  year={2013},
  volume={28 3},
  pages={220-9}
}
OBJECTIVES We investigated whether nicotine dependence affects these endophenotypes in Japanese schizophrenia patients and whether alpha4 and beta2 subunits of neuronal nicotinic acetylcholine receptor genes (alpha4 subunit of the nAChR gene (CHRNA4)/beta2 subunit of the nAChR gene (CHRNB2)) were associated with nicotine dependence in patients (n = 100) and healthy controls (n = 107). METHODS First, in patients, we evaluated cognitive function, using the Brief Assessment of Cognition in… CONTINUE READING

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