Relationship between mutagenic potency in Salmonella typhimurium and chemical structure of amino- and nitro-substituted biphenyls.

@article{Nohara1985RelationshipBM,
  title={Relationship between mutagenic potency in Salmonella typhimurium and chemical structure of amino- and nitro-substituted biphenyls.},
  author={Masahiko Nohara and Teruhisa Hirayama and Yuko Fujioka and S Ozasa and Eri Ibuki and Saburo Fukui},
  journal={Mutation research},
  year={1985},
  volume={149 1},
  pages={9-15}
}
All positional isomers of mononitro- and monoaminobiphenyls and those of dinitro-, diamino- and aminonitrobiphenyls, which have one substituent on each benzene ring, were assayed for mutagenicity in Salmonella typhimurium by the Ames method. The results suggest that the structural requirements favoring mutagenic activity are the presence of substituents at the 4-position and their absence at the 2'-position. The introduction of an amino group to the 3'- or 4'-position of 4-nitrobiphenyl or a… CONTINUE READING