Relationship between mood changes and adrenal cortical activity in a patient with 48-hour unipolar-depressive cycles.

@article{Doerr1979RelationshipBM,
  title={Relationship between mood changes and adrenal cortical activity in a patient with 48-hour unipolar-depressive cycles.},
  author={Peter Doerr and Detlev von Zerssen and Marc Fischler and H K Schulz},
  journal={Journal of affective disorders},
  year={1979},
  volume={1 2},
  pages={93-104}
}
A 66-year-old patient with 48-hour unipolar-depressive cycles was studied in the hospital for one month and in an isolation unit for two weeks. At 3-hour intervals during the day and once at night the mood state was assessed by two self-rating scales and urine was collected for the determination of urinary free cortisol (UFC). In the hospital there was a regular alternation between 'good' and 'bad' days. Without exception the switch from normal to depressive mood occurred between 22:00 and 2:30… CONTINUE READING