Relationship between microtubule-binding repeats and morphology of neurofibrillary tangle in Alzheimer's disease.

@article{Kitamura2005RelationshipBM,
  title={Relationship between microtubule-binding repeats and morphology of neurofibrillary tangle in Alzheimer's disease.},
  author={Tatsuru Kitamura and Kaoru Sugimori and Satoru Sudo and Katsuji Kobayashi},
  journal={Acta neurologica Scandinavica},
  year={2005},
  volume={112 5},
  pages={327-34}
}
OBJECTIVE The present study was performed to compare the distributions of three-repeat (3R) and four-repeat (4R) neurofibrillary tangles (NFT) with those of pretangles (p-NFT), intracellular NFT (i-NFT), and extracellular NFT (e-NFT) in the hippocampus of Alzheimer's disease brains. METHODS NFT labeling was performed using anti-tau antibodies: pSer262 for p-NFT, pSer422 for i-NFT, AT8 for e-NFT, RD3 for 3R, and RD4 for 4R tau, and Gallyas impregnation for the NFT population. RD4- and pSer422… CONTINUE READING

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