Relationship between mevalonate pathway and arterial myocyte proliferation: in vitro studies with inhibitors of HMG-CoA reductase.

@article{Corsini1993RelationshipBM,
  title={Relationship between mevalonate pathway and arterial myocyte proliferation: in vitro studies with inhibitors of HMG-CoA reductase.},
  author={Alberto Corsini and Marco Mazzotti and M Raiteri and Mithitaka Soma and Giulio Gabbiani and Remo Fumagalli and Rodolfo Paoletti},
  journal={Atherosclerosis},
  year={1993},
  volume={101 1},
  pages={117-25}
}
The role of mevalonate and its products (isoprenoids) in the control of cellular proliferation was examined by investigating the effect of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (vastatins) on growth and on cholesterol biosynthesis of cultured arterial myocytes (SMC). Simvastatin (S) and fluvastatin (F), but not pravastatin (P), decreased the rate of growth of rat vascular SMC. The inhibition, evaluated as cell number, was dose-dependent with IC50 values of 2.8 and… CONTINUE READING

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