Relationship between mephenytoin, phenytoin and tolbutamide hydroxylations in healthy African subjects.

@article{Horsmans1996RelationshipBM,
  title={Relationship between mephenytoin, phenytoin and tolbutamide hydroxylations in healthy African subjects.},
  author={Yves Horsmans and J M Kanyinda and J. P. Desager},
  journal={Pharmacology & toxicology},
  year={1996},
  volume={78 2},
  pages={86-8}
}
Mephenytoin, phenytoin and tolbutamide are metabolised by the cytochrome P-450 (CYP) 2C family. Recently, it has been shown that phenytoin and tolbutamide are metabolised by CYP2C9/10 whereas mephenytoin is metabolised by CYP2C19. Until now, in vivo studies were only undertaken in Caucasian subjects and showed a strong relationship between phenytoin and tolbutamide metabolism but no significant relationship between the two drug metabolisms and that of mephenytoin. The metabolism of the three… CONTINUE READING