Relationship between lipophilicity and antitumor activity of molecule library of Mannich ketones determined by high-performance liquid chromatography, clogP calculation and cytotoxicity test.

Abstract

A series of Mannich ketones were synthesized in order to study the relative importance of structure and specific substitutions in relation to their lipophilicity and antitumor activity. Substitutions were carried out with morpholinyl, pirrolidinyl, piperidyl and tetrahydro-isoquinolyl groups in various positions on three different skeletons. Lipophilicity… (More)

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Cite this paper

@article{Hollsy2002RelationshipBL, title={Relationship between lipophilicity and antitumor activity of molecule library of Mannich ketones determined by high-performance liquid chromatography, clogP calculation and cytotoxicity test.}, author={Ferenc Holl{\'o}sy and Tam{\'a}s L{\'o}r{\'a}nd and L{\'a}szlȯ Őrfi and D{\'a}niel Er{\"{o}s and Gy{\"{o}rgy K{\'e}ri and Mikl{\'o}s Idei}, journal={Journal of chromatography. B, Analytical technologies in the biomedical and life sciences}, year={2002}, volume={768 2}, pages={361-8} }