Relationship between lipophilicities of 1,4-dihydropyridine derivatives and pharmacokinetic interaction strengths with grapefruit juice.

@article{Uesawa2008RelationshipBL,
  title={Relationship between lipophilicities of 1,4-dihydropyridine derivatives and pharmacokinetic interaction strengths with grapefruit juice.},
  author={Yoshihiro Uesawa and Kiminori Mohri},
  journal={Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan},
  year={2008},
  volume={128 1},
  pages={
          117-22
        }
}
It is well known fact that the strengths of drug interactions with grapefruit juice (GFJ) differ greatly depending on the 1,4-dihydropyridine calcium channel antagonist (DHP) used. However, there are no available data on the relationship between interactions with GFJ and its physicochemical attributes. Therefore we endeavored to study the correlation between calculated logP values, indicating lipophilicity, from chemical structures of DHPs as well as water diffusion, molecular volume, molecular… CONTINUE READING

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