Relationship between leukemia antigens and stimulation in mixed leukocyte culture.

@article{Opelz1977RelationshipBL,
  title={Relationship between leukemia antigens and stimulation in mixed leukocyte culture.},
  author={Gerhard Opelz and Robert Peter Gale and Julie McClelland},
  journal={Journal of the National Cancer Institute},
  year={1977},
  volume={59 1},
  pages={95-8}
}
Leukemia cells from 13 of 27 patients stimulated lymphocytes of their HLA-identical siblings in mixed leukocyte cultures (MLC). Stimulation correlated with high background uptake of tritiated thymidine and high percentages of cells that stained with fluorescein-conjugated polyvalent goat antiserum against human immunoglobulin. Results were similar to those reported with fractionated autologous lymphocyte subpopulations in normal individuals. Investigation of leukemia-specific stimulation in MLC… CONTINUE READING