Relationship between lactone ring forms of HCPT and their antitumor activities.

@article{Yuen2001RelationshipBL,
  title={Relationship between lactone ring forms of HCPT and their antitumor activities.},
  author={Kwok-Yung Yuen and John T C Liu and Bao-bin Xu},
  journal={Acta pharmacologica Sinica},
  year={2001},
  volume={22 9},
  pages={827-30}
}
AIM To study the relationship between the lactone forms of 10-hydroxycamptothecin (HCPT) and their antitumor activities. METHODS Antitumor activity of the two forms of HCPT was studied in vitro using seven cultured human and mouse tumor cell lines. Mice bearing sarcoma 180 and solid hepatoma were treated with HCPT (0.5, 1, and 2 mg/kg, ip) and tumor growth inhibition was assayed. HPLC method was employed to investigate the conversion of two forms of HCPT in different pH conditions and… CONTINUE READING
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